Systems Analysis of Ran Transport

Alicia E. Smith, Boris M. Slepchenko, James C. Schaff, Leslie M. Loew, Ian G. Macara.
Science. 2002 Jan 18;295(5554):488-91


To access, view or copy the models described in this paper, log on to the Virtual Cell software and go to File>Open>MathModel. In the MathModel Database dialog, scroll down and open MathModel Neighborhood.Three public math models can be accessed under user 'boris' :

AliciaProblem1_5
 Basic nonspatial model used to obtain results published in the Science paper.
AliciaProblem1_5Fast As in AliciaProblem1_5 but the reactions with mass action kinetics are treated as fast; this model was used to obtain initial conditions for spatial simulations.
AliciaSpatial_NewFast The basic spatial model used in the Science paper.


The public Biomodel can be found under user 'les' and is entitled 'Smith et al System Analysis of Ran Transport'. This is a later version and is corrected for the competiton between RanGDP and NTF2:RanGDP for the same site on RCC1.